Article
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.
Diabetologia - 1 Jun 2014
Sandholm Niina, Forsblom Carol, Mäkinen Ville-Petteri, McKnight Amy Jayne, Osterholm Anne-May, He Bing, Harjutsalo Valma, Lithovius Raija, Gordin Daniel, Parkkonen Maija, Saraheimo Markku, Thorn Lena M, Tolonen Nina, Wadén Johan, Tuomilehto Jaakko, Lajer Maria, Ahlqvist Emma, Möllsten Anna, Marcovecchio M Loredana, Cooper Jason, Dunger David, Paterson Andrew D, Zerbini Gianpaolo, Groop Leif, Tarnow Lise, Maxwell Alexander P, Tryggvason Karl, Groop Per-Henrik
Abstract excerpt
AIMS/HYPOTHESIS: An abnormal urinary albumin excretion rate (AER) is often the first clinically detectable manifestation of diabetic nephropathy. Our aim was to estimate the heritability and to detect genetic variation associated with elevated AER in patients with type 1 diabetes. METHODS: The discovery phase genome-wide association study (GWAS) included 1,925 patients with type 1 diabetes and with data on 24 h...
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