Macrophage Phenotype and Function in Different Stages of Atherosclerosis.

doi:10.1161/CIRCRESAHA.115.306256

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Article

Macrophage Phenotype and Function in Different Stages of Atherosclerosis.

Circulation research - 19 Feb 2016

Tabas Ira, Bornfeldt Karin E

Abstract excerpt

The remarkable plasticity and plethora of biological functions performed by macrophages have enticed scientists to study these cells in relation to atherosclerosis for >50 years, and major discoveries continue to be made today. It is now understood that macrophages play important roles in all stages of atherosclerosis, from initiation of lesions and lesion expansion, to necrosis leading to rupture and the...

Topics

Animals
Arteries
Atherosclerosis
Cell Differentiation
Cellular Microenvironment
Cholesterol
Foam Cells
Humans
Inflammation Mediators
Macrophages
Phenotype
Plaque, Atherosclerotic
Signal Transduction

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Identifiers

PMID: 26892964
DOI: 10.1161/CIRCRESAHA.115.306256
PMCID: PMC4762068

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