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Article

Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum.

Molecular pharmacology - 1 Jun 2010

Málaga-Diéguez Laura, Yang Qiong, Bauer Jan, Pankevych Halyna, Freissmuth Michael, Nanoff Christian

Abstract excerpt

Exchanging each of the conserved aromatic residues of the NPxxY(x)(5,6)F sequence (at the boundary of helices 7 and 8) generated variants of the A(1) adenosine receptor that were retained within the cell. The mutations disconnected a link between alpha-helix 7 and cytosolic helix 8, likely destabilizing the structure of the proximal carboxyl terminus. The mutant receptors were rescued by incubation of cells with...

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Identifiers

PMID: 20219842
DOI: 10.1124/mol.110.063511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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