Article
[Antioncogenes: models for tumors in children].
Bulletin du cancer - 1 Jan 1991
Junien C, Henry I, Jeanpierre C, Lavedan C, Antignac C, Puech A, Beroud C
Abstract excerpt
The chromosomal assignment of genes responsible for malformation syndromes associated with increased susceptibility to malignancy could be determined owing to specific constitutional chromosomal abnormalities or to family studies. For certain types of tumors, somatic chromosomal rearrangements (loss of alleles) occur at the same locus indicating the presence of a recessive suppressor gene or an antioncogène. For...
Topics
- Alleles
- Congenital Abnormalities
- Cytogenetics
- DNA Repair
- Disease Susceptibility
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Mutation
- Neoplasms
- Proto-Oncogenes