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Article

Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications.

Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2010

Lipinski Robert J, Song Chihwa, Sulik Kathleen K, Everson Joshua L, Gipp Jerry J, Yan Dong, Bushman Wade, Rowland Ian J

Abstract excerpt

BACKGROUND: The Hedgehog (Hh) pathway provides inductive signals critical for developmental patterning of the brain and face. In humans and in animal models interference with this pathway yields birth defects, among the most well-studied of which fall within the holoprosencephaly (HPE) spectrum....

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Identifiers

PMID: 20213699
DOI: 10.1002/bdra.20656
PMCID: PMC2922848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20213699-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications.PMID 20213699Read ↗

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