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Article

[Hedgehog pathway antagonist-induced oromandibular limb hypogenesis in mouse].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology - 9 Jan 2018

Jiang Y J, Mao C Q, Lai Y Z, Weng Y P, Zhang S X, Chen W H

Abstract excerpt

Objective: To analysis teratogenic effect of GDC-0449 to fetus and set up the animal model of GDC-0449 induced oromandibular limb hypogenesis in mouse for further research of its pathogenesis. Methods: Twenty-seven pregnant Institute of Cancer Research (ICR) mice were randomly divided into: control group, embryonic day 8.5 (E8.5) exposed groups, E9.5 exposed groups, E10.5 exposed groups, E11.5 exposed groups,...

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Identifiers

PMID: 29972962
DOI: 10.3760/cma.j.issn.1002-0098.2018.01.008

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