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Article

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly.

Cellular and molecular life sciences : CMLS - 1 Nov 2000

Incardona J P, Roelink H

Abstract excerpt

Holoprosencephaly, or an undivided forebrain, is a complex brain malformation associated with Sonic hedgehog (Shh) mutations. Other causes of holoprosencephaly have converged upon the Shh signaling pathway: genetic and pharmacologic impairment of cholesterol synthesis, and the action of the steroidal alkaloid cyclopamine. This review focuses on recent studies aimed at determining how Shh signaling is affected by...

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Identifiers

PMID: 11130177
DOI: 10.1007/PL00000653
PMCID: PMC11146831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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