Article

Heme oxygenase limits mycobacterial infection-induced ferroptosis

2021-05-04

Abstract excerpt

Iron homeostasis is essential for both sides of the host-pathogen interface. Restricting access of iron slows bacterial growth while iron is also a necessary co-factor for host immunity. Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme. It is also a stress-responsive protein that can be rapidly upregulated and confers protection t...

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Literature Corpus work: 90ed66b7-8908-52f3-8e2f-c41fd02c5ad4
DOI: 10.1101/2021.05.04.442683

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