Article
One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome.
Gastroenterology - 1 Jun 2010
Vasen Hans F A, Abdirahman Mohamed, Brohet Richard, Langers Alexandra M J, Kleibeuker Jan H, van Kouwen Mariette, Koornstra Jan Jacob, Boot Henk, Cats Annemieke, Dekker Evelien, Sanduleanu Silvia, Poley Jan-Werner, Hardwick James C H, de Vos Tot Nederveen Cappel Wouter H, van der Meulen-de Jong Andrea E, Tan T Gie, Jacobs Maarten A J M, Mohamed Faig Lall A, de Boer Sijbrand Y, van de Meeberg Paul C, Verhulst Marie-Louise, Salemans Jan M, van Bentem Nico, Westerveld B Dik, Vecht Juda, Nagengast Fokko M
Abstract excerpt
BACKGROUND & AIMS: Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended since 1995. The aim of the study was to evaluate the effectiveness of this program. METHODS: The...
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