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Article

Formation of heteromeric Kv2 channels in mammalian brain neurons.

The Journal of biological chemistry - 14 May 2010

Kihira Yoshitaka, Hermanstyne Tracey O, Misonou Hiroaki

Abstract excerpt

The formation of heteromeric tetramers is a common feature of voltage-gated potassium (Kv) channels. This results in the generation of a variety of tetrameric Kv channels that exhibit distinct biophysical and biochemical characteristics. Kv2 delayed rectifier channels are, however, unique exceptions. It has been previously shown that mammalian Kv2.1 and Kv2.2 are localized in distinct domains of neuronal...

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Identifiers

PMID: 20202934
DOI: 10.1074/jbc.M109.074260
PMCID: PMC2865335

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