Article
Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.
The Journal of clinical investigation - 1 Mar 2010
Tanaka Mari, Asada Misako, Higashi Atsuko Y, Nakamura Jin, Oguchi Akiko, Tomita Mayumi, Yamada Sachiko, Asada Nariaki, Takase Masayuki, Okuda Tomohiko, Kawachi Hiroshi, Economides Aris N, Robertson Elizabeth, Takahashi Satoru, Sakurai Takeshi, Goldschmeding Roel, Muso Eri, Fukatsu Atsushi, Kita Toru, Yanagita Motoko
Abstract excerpt
The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previousl...
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