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Article

Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.

Lancet (London, England) - 3 Dec 2005

Jambou Ronan, Legrand Eric, Niang Makhtar, Khim Nimol, Lim Pharath, Volney Béatrice, Ekala Marie Thérèse, Bouchier Christiane, Esterre Philippe, Fandeur Thierry, Mercereau-Puijalon Odile

Abstract excerpt

Artemisinin derivatives are an essential component of treatment against multidrug-resistant Plasmodium falciparum malaria. We aimed to investigate in-vitro resistance to artemisinin derivatives in field isolates. In-vitro susceptibility of 530 P falciparum isolates from three countries (Cambodia, French Guiana, and Senegal) with different artemisinin use was assessed with an isotopic microtest. Artemether IC50 up...

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PMID: 16325698
DOI: 10.1016/S0140-6736(05)67787-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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