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Article

Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.

Applied and environmental microbiology - 1 May 2010

Lee Han-Na, Huang Jianqiang, Im Jong-Hyuk, Kim Seon-Hye, Noh Jun-Hee, Cohen Stanley N, Kim Eung-Soo

Abstract excerpt

A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic...

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Identifiers

PMID: 20190084
DOI: 10.1128/AEM.02426-09
PMCID: PMC2863465

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Source receipt: pubmed, retrieved 7 Sept 2026.

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