Article
1H NMR based pharmacometabolomics analysis of metabolic phenotype on predicting metabolism characteristics of losartan in healthy volunteers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 15 Sept 2018
He Chenjie, Liu Yongbin, Wang Yicheng, Tang Jie, Tan Zhirong, Li Xi, Chen Yao, Huang Yuanfei, Chen Xiaoping, Ouyang Dongsheng, Zhou Honghao, Peng Jingbo
Abstract excerpt
Inter-individual variability in drug metabolism and disposition is common in both preclinical and clinical researches. Losartan and its active metabolite EXP3174 present a high degree of inter-individual differences in blood concentrations that affect drug efficacy and side effect. Pharmacometabolomics has been increasingly applied on predicting the drug responses by analyzing the differences in metabolic...
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