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Article

Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.

Bioorganic & medicinal chemistry - 15 Mar 2010

Darvesh Sultan, Pottie Ian R, Darvesh Katherine V, McDonald Robert S, Walsh Ryan, Conrad Sarah, Penwell Andrea, Mataija Diane, Martin Earl

Abstract excerpt

A series of N-10 urea derivatives of phenothiazine was synthesized and each compound was evaluated for its ability to inhibit human cholinesterases. Most were specific inhibitors of BuChE. However, the potent inhibitory effects on both cholinesterases of one sub-class, the cationic aminoureas, pr...

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Identifiers

PMID: 20181484
DOI: 10.1016/j.bmc.2010.01.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20181484-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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