Article
PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2006
Soncini Chiara, Carpinelli Patrizia, Gianellini Laura, Fancelli Daniele, Vianello Paola, Rusconi Luisa, Storici Paola, Zugnoni Paola, Pesenti Enrico, Croci Valter, Ceruti Roberta, Giorgini Maria Laura, Cappella Paolo, Ballinari Dario, Sola Francesco, Varasi Mario, Bravo Rodrigo, Moll Jürgen
Abstract excerpt
PURPOSE: Aurora kinases play critical roles during mitosis in chromosome segregation and cell division. The aim of this study was to determine the preclinical profile of a novel, highly selective Aurora kinase inhibitor, PHA-680632, as a candidate for anticancer therapy. EXPERIMENTAL DESIGN: The activity of PHA-680632 was assayed in a biochemical ATP competitive kinase assay. A wide panel of cell lines was...
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