Animal HECT ubiquitin ligases: evolution and functional implications

Abstract excerpt

BACKGROUND: HECT ubiquitin ligases (HECT E3s) are key components of the eukaryotic ubiquitin-proteasome system and are involved in the genesis of several human diseases. In this study, I analyze the patterns of diversification of HECT E3s since animals emerged in order to provide the right framework to understand the functional data available for proteins of this family. RESULTS: I show that the current...

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