Article
Animal models for studying neural crest development: is the mouse different?
Development (Cambridge, England) - 1 May 2015
Barriga Elias H, Trainor Paul A, Bronner Marianne, Mayor Roberto
Abstract excerpt
The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these...
Topics
- Animals
- Chick Embryo
- Gene Expression Regulation, Developmental
- Gene Knockout Techniques
- Mice
- Models, Animal
- Neural Crest
- Phenotype
- Species Specificity
- Xenopus
- Zebrafish