Article
Risk alleles for multiple sclerosis in multiplex families.
Neurology - 9 Jun 2009
D'Netto M J, Ward H, Morrison K M, Ramagopalan S V, Dyment D A, DeLuca G C, Handunnetthi L, Sadovnick A D, Ebers G C
Abstract excerpt
OBJECTIVE: We assessed the hypotheses that non-major histocompatibility complex multiple sclerosis (MS) susceptibility loci would be common to sporadic cases and multiplex families, that they would have larger effects in multiplex families, and that the aggregation of susceptibility loci contributes to the increased prevalence of MS in such families. METHODS: A set of 43 multiplex families comprising 732...
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