Article
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains.
Neurobiology of aging - 1 Jan 2006
Mishto Michele, Bellavista Elena, Santoro Aurelia, Stolzing Alexandra, Ligorio Claudia, Nacmias Benedetta, Spazzafumo Liana, Chiappelli Martina, Licastro Federico, Sorbi Sandro, Pession Annalisa, Ohm Thomas, Grune Tilman, Franceschi Claudio
Abstract excerpt
In this study, we investigated the presence and role of immunoproteasome and its LMP2 subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was present in brain areas such as hippocampus and cerebellum and localized in neurons, astrocytes and endothelial cells. A higher expression of immunoproteasome was found in brain of AD patients than in brain of non-demented elderly, being its...
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