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Article

Accurate prediction of BRCA1 and BRCA2 heterozygous genotype using expression profiling after induced DNA damage.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2006

Kote-Jarai Zsofia, Matthews Lucy, Osorio Ana, Shanley Susan, Giddings Ian, Moreews Francois, Locke Imogen, Evans D Gareth, Eccles Diana, Williams Richard D, Girolami Mark, Campbell Colin, Eeles Ros

Abstract excerpt

PURPOSE: In this study, the differential gene expression changes following radiation-induced DNA damage in healthy cells from BRCA1/BRCA1 mutation carriers have been compared with controls using high-density microarray technology. We aimed to establish if BRCA1/BRCA2 mutation carriers could be distinguished from noncarriers based on expression profiling of normal cells. EXPERIMENTAL DESIGN: Short-term primary...

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Identifiers

PMID: 16818684
DOI: 10.1158/1078-0432.CCR-05-2805

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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