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Article

Database of homology-derived protein structures and the structural meaning of sequence alignment.

Proteins - 1 Jan 1991

Sander C, Schneider R

Abstract excerpt

The database of known protein three-dimensional structures can be significantly increased by the use of sequence homology, based on the following observations. (1) The database of known sequences, currently at more than 12,000 proteins, is two orders of magnitude larger than the database of known structures. (2) The currently most powerful method of predicting protein structures is model building by homology. (3)...

Topics

Amino Acid Sequence
Animals
Calibration
Databases, Factual
Genetic Variation
Molecular Sequence Data
Protein Conformation
Proteins
Reproducibility of Results
Sequence Homology, Nucleic Acid
Stereoisomerism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thermodynamics

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Identifiers

PMID: 2017436
DOI: 10.1002/prot.340090107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2017436-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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