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Article

Can three-dimensional contacts in protein structures be predicted by analysis of correlated mutations?

Protein engineering - 1 Mar 1994

Shindyalov I N, Kolchanov N A, Sander C

Abstract excerpt

A method has been developed to detect pairs of positions with correlated mutations in protein multiple sequence alignments. The method is based on reconstruction of the phylogenetic tree for a set of sequences and statistical analysis of the distribution of mutations in the branches of the tree. The database of homology-derived protein structures (HSSP) is used as the source of multiple sequence alignments for...

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PMID: 8177884
DOI: 10.1093/protein/7.3.349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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