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Article

Structure-function relationships of two loss-of-function mutations of the thyrotropin receptor gene.

Thyroid : official journal of the American Thyroid Association - 1 Oct 1999

Costagliola S, Sunthorntepvarakul T, Migeotte I, Van Sande J, Kajava A M, Refetoff S, Vassart G

Abstract excerpt

The functional and structural characteristics of two previously described "loss-of-function" mutants of the thyrotropin receptor (TSHR) gene were analyzed by transient transfection in COS cells. Both mutations (Pro162Ala, Ile167Asn) are located in the putative extracellular hormone-binding domain of the receptor. The following parameters were analyzed: expression of native receptor on the cell surface (as...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10560953
DOI: 10.1089/thy.1999.9.995

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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