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Article

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Feb 2010

Wu Hai-Yan, Hudry Eloise, Hashimoto Tadafumi, Kuchibhotla Kishore, Rozkalne Anete, Fan Zhanyun, Spires-Jones Tara, Xie Hong, Arbel-Ornath Michal, Grosskreutz Cynthia L, Bacskai Brian J, Hyman Bradley T

Abstract excerpt

Amyloid beta (Abeta)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's disease (AD) brain, but whether and how plaques induce these neuritic abnormalities remain unknown. We tested the hypothesis that soluble oligomeric assemblies of Abeta, which surround plaques, induce...

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Identifiers

PMID: 20164348
DOI: 10.1523/JNEUROSCI.4456-09.2010
PMCID: PMC2841957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20164348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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