Article

Characterization of a Novel Prion Protein Mutation of Serine to Proline at Residue 245 Linked to VPSPr-like PK-Resistant PrPSc

2026-06-22

Abstract excerpt

<title>Abstract</title> <p> More than 50 deleterious mutations in the prion protein (PrP) have been linked to genetic human prion diseases to date. All but two of the mutations reported so far localize within the mature PrP between residues 23 and 231. Here, we identify a novel mutation of serine (S) to proline (P) at residue 245 of PrP (PrP <sup>S245P</sup> ) that is in the C-terminal signal peptide region of...

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Literature Corpus work: 7f896d88-433c-59f2-a00b-d09c81a96ff1
DOI: 10.21203/rs.3.rs-9901432/v1

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