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Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2010

Pollex Erika K, Anger Gregory, Hutson Janine, Koren Gideon, Piquette-Miller Micheline

Abstract excerpt

The antidiabetic agent glyburide (glibenclamide) is frequently used for the treatment of type II diabetes and is increasingly being used for the treatment of gestational diabetes. Evidence suggests that breast cancer resistance protein/ATP-binding cassette, subfamily G, member 2 (ABCG2) expressed in the placenta protects the fetus against the accumulation of glyburide. A number of studies have investigated the...

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ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters
Biological Transport, Active
Cell Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

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PMID: 20159988
DOI: 10.1124/dmd.109.030791

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ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism.PMID 20159988Read ↗

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