Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2010

Pollex Erika K, Anger Gregory, Hutson Janine, Koren Gideon, Piquette-Miller Micheline

Abstract excerpt

The antidiabetic agent glyburide (glibenclamide) is frequently used for the treatment of type II diabetes and is increasingly being used for the treatment of gestational diabetes. Evidence suggests that breast cancer resistance protein/ATP-binding cassette, subfamily G, member 2 (ABCG2) expressed in the placenta protects the fetus against the accumulation of glyburide. A number of studies have investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Biological Transport, Active

Share to Cell Membrane

Share to Cytoplasm

Share to Glyburide

Share to Indoles

Share to Neoplasm Proteins

Source

Identifiers

PMID: 20159988
DOI: 10.1124/dmd.109.030791

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism.PMID 20159988Read ↗

BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications.Semantic proximity Read ↗

Quantitative Analysis of the ABCG2 c.421C>A Polymorphism Effect on In Vivo Transport Activity of Breast Cancer Resistance Protein (BCRP) Using an Intestinal Absorption Model.Semantic proximity Read ↗

Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology.Semantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

Drug transport by breast cancer resistance proteinSemantic proximity Read ↗

Functional analysis of SNPs variants of BCRP/ABCG2.Semantic proximity Read ↗

Natural allelic variants of bovine ATP-binding cassette transporter ABCG2: increased activity of the Ser581 variant and development of tools for the discovery of new ABCG2 inhibitors.Semantic proximity Read ↗

Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancySemantic proximity Read ↗

Genetic variation in the ATP-binding cassette transporter gene ABCG2 (BCRP) in a Swedish population.Semantic proximity Read ↗

BCRP/ABCG2 in the Placenta: Expression, Function and RegulationSemantic proximity Read ↗

[Functional SNPs of the breast cancer resistance protein (ABCG2) gene altering the pharmacokinetics/pharmacodynamics of anticancer agents].Semantic proximity Read ↗

Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.