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Article

A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.

Human molecular genetics - 15 May 2010

Iijima-Ando Kanae, Zhao LiJuan, Gatt Anthony, Shenton Christopher, Iijima Koichi

Abstract excerpt

Hyperphosphorylation of the microtubule associated protein tau is detected in the brains of individuals with a range of neurodegenerative diseases including Alzheimer's disease (AD). An imbalance in phosphorylation and/or dephosphorylation of tau at disease-related sites has been suggested to ini...

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Identifiers

PMID: 20159774
DOI: 10.1093/hmg/ddq068
PMCID: PMC2860892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159774-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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