Article
The role of mitochondria in the pathogenesis of neurodegenerative diseases.
Brain pathology (Zurich, Switzerland) - 1 Jul 2000
Manfredi G, Beal M F
Abstract excerpt
A growing body of evidence indicates that mitochondrial dysfunction may play an important role in the pathogenesis of many neurodegenerative disorders. Because mitochondrial metabolism is not only the principal source of high energy intermediates, but also of free radicals, it has been suggested that inherited or acquired mitochondrial defects could be the cause of neuronal degeneration as a consequence of energy...
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