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Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8

8 Nov 2010

Abstract excerpt

BACKGROUND: Thiadiazolidinones (TDZD) are small heterocyclic compounds first described as non-ATP competitive inhibitors of glycogen synthase kinase 3β (GSK-3β). In this study, we analyzed the effects of 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), on murine GL261 cells growth in vitro and on the growth of established intracerebral murine gliomas in vivo. METHODOLOGY/PRINCIPAL FINDINGS: Our data...

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PMID: 21079728
DOI: 10.1371/journal.pone.0013879

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