Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy

15 Oct 2024

Abstract excerpt

Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skeletal defects, brain calcification, and vascular anomalies. The research on small molecule inhibitors targeting PDGFRβ in cancer treatment has seen promising...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Berberine and alkaloids research
Share to Quinazolinone synthesis and applications
Share to Synthesis and biological activity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39473823
DOI: 10.3389/fmolb.2024.1492847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapyPMID 39473823Read ↗

Natural Sourced Inhibitors of EGFR, PDGFR, FGFR and VEGFRMediated Signaling Pathways as Potential Anticancer AgentsSemantic proximity Read ↗

The PDGF/PDGFR pathway as a drug target.Semantic proximity Read ↗

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological TargetsSemantic proximity Read ↗

Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastomaSemantic proximity Read ↗

The Role of Natural Products as Inhibitors of JAK/STAT Signaling Pathways in Glioblastoma TreatmentSemantic proximity Read ↗

Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular DockingSemantic proximity Read ↗

Mechanism and Molecular Targets of Songhe Guxue Formula for Treating Cancer Therapy-Introduced Thrombocytopenia—Based on Clinical Observation, Network Pharmacology, and Molecular DockingSemantic proximity Read ↗

Medicinal Chemistry Strategies in Targeting TGF-βR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR)Semantic proximity Read ↗

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic DiseasesSemantic proximity Read ↗

Exploration in the Mechanism of Ginsenoside Rg5 for the Treatment of Osteosarcoma by Network Pharmacology and Molecular DockingSemantic proximity Read ↗

Network pharmacology and experimental validation reveal Salvia miltiorrhiza’s renoprotective mechanisms via PI3K-Akt pathway in diabetic nephropathySemantic proximity Read ↗

Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.