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Article

Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging.

PloS one - 1 Jan 2012

Tang Xinyan, Jing Liufang, Chen Jun

Abstract excerpt

Intervertebral disc (IVD) disorder and age-related degeneration are believed to contribute to low back pain. Cell-based therapies represent a promising strategy to treat disc degeneration; however, the cellular and molecular characteristics of disc cells during IVD maturation and aging still remain poorly defined. This study investigated novel molecular markers and their age-related changes in the rat IVD....

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Source

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Identifiers

PMID: 23284858
DOI: 10.1371/journal.pone.0052020
PMCID: PMC3526492

Genes

IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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