Article
Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa.
PloS one - 9 Jul 2010
Oleksyk Taras K, Nelson George W, An Ping, Kopp Jeffrey B, Winkler Cheryl A
Abstract excerpt
MYH9 was recently identified as renal susceptibility gene (OR 3-8, p < 10(-8)) for major forms of kidney disease disproportionately affecting individuals of African descent. The risk haplotype (E-1) occurs at much higher frequencies in African Americans (> or = 60%) than in European Americans (< 4%), revealing a genetic basis for a major health disparity. The population distributions of MYH9 risk alleles and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.