Article
Strong dependence between functional domains in a dual-function snoRNA infers coupling of rRNA processing and modification events.
Nucleic acids research - 1 Jun 2010
Liang Xue-hai, Liu Qing, Liu Quansheng, King Thomas H, Fournier Maurille J
Abstract excerpt
Most small nucleolar RNAs (snoRNAs) guide rRNA nucleotide modifications, some participate in pre-rRNA cleavages, and a few have both functions. These activities involve direct base-pairing of the snoRNA with pre-rRNA using different domains. It is not known if the modification and processing functions occur independently or in a coordinated manner. We address this question by mutational analysis of a yeast box...
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