Article
Colorectal cancer susceptibility quantitative trait loci in mice as a novel approach to detect low-penetrance variants in humans: a two-stage case-control study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2010
Fernández-Rozadilla Ceres, Tarrío Rosa, Clofent Juan, de Castro Luisa, Brea-Fernández Alejandro, Bessa Xavier, Abulí Anna, Andreu Montserrat, Jover Rodrigo, Xicola Rosa, Llor Xavier, Castells Antoni, Castellví-Bel Sergi, Carracedo Angel, Ruiz-Ponte Clara
Abstract excerpt
Thirty-five percent of colorectal cancer (CRC) susceptibility is thought to be attributable to genetics, but only a small proportion of the cases (<6%) can be explained by highly penetrant mutations. The rest of the susceptibility could be explained by a number of low-penetrance variants followin...
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