Article
Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia.
Schizophrenia research - 1 May 2010
Prasad Konasale M, Bamne Mikhil N, Shirts Brian H, Goradia Dhruman, Mannali Vimal, Pancholi Krishna M, Xue Bai, McClain Lora, Yolken Robert H, Keshavan Matcheri S, Nimgaonkar Vishwajit L
Abstract excerpt
BACKGROUND: We previously reported reduced prefrontal cortex (PFC) grey matter volume among first episode, antipsychotic-naïve schizophrenia subjects (SZ) exposed to HSV1 but not among healthy subjects (HS) (Prasad et al., 2007). Independently, rs1051788, an exonic polymorphism of the MHC Class I polypeptide-related sequence B (MICB) gene was associated with HSV1 seropositivity, as well as SZ risk. In this study,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.