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Article

A Multistage Murine Breast Cancer Model Reveals Long-Lived Premalignant Clones Refractory to Parity-Induced Protection.

Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2020

Li Shuo, Gestl Shelley A, Gunther Edward J

Abstract excerpt

Breast cancers evolve in a multistage process that can span decades after a carcinogenic exposure. It follows that long-lived precursor breast lesions persist in a subclinical state prior to completing malignant transformation, yet widely used breast cancer models lack an experimental framework for targeting premalignant disease. Inspired by classic multistage skin carcinogenesis protocols, we combined chemical...

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Identifiers

PMID: 31699706
DOI: 10.1158/1940-6207.CAPR-19-0322
PMCID: PMC7007345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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