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Article

Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development

30 Jan 2012

Abstract excerpt

Cell fate determination is tightly regulated by transcriptional activators and repressors. Leukemia/lymphoma-related factor (LRF; encoded by Zbtb7a), known as a POK (POZ/BTB and Krüppel) family transcriptional repressor, is induced during the development of bone-resorbing osteoclasts, but the physiological significance of LRF in bone metabolism and the molecular mechanisms underlying the transcriptional...

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PMID: 22308398
DOI: 10.1073/pnas.1116042109

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