Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population.

doi:10.1016/j.clinbiochem.2010.01.008

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Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population.

Clinical biochemistry - 1 Apr 2010

Bouhaha Rym, Baroudi Thouraya, Ennafaa Hajer, Vaillant Emanuel, Abid Hafawa, Sassi Rim, Vatin Vincent, Froguel Philippe, Gaaied Amel Benammar-el, Meyre David, Vaxillaire Martine

Abstract excerpt

OBJECTIVES: We investigated two genetic markers in pro inflammatory molecules : TNFalpha -308G/A and IL6 -174G/C in order to assess their effect on type 2 diabetes (T2D) and obesity in the Tunisian population. DESIGN AND METHODS: The study sample includes 228 patients with T2D and 300 healthy controls. Genotyping of IL6 -174G/C (rs1800795) was performed using Automated Dye Terminator Sequencing and of TNFalpha...

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PMID: 20132806
DOI: 10.1016/j.clinbiochem.2010.01.008

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