Article
Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.
Molecular biology of the cell - 1 Apr 2010
Cheng Jie, Cebotaru Valeriu, Cebotaru Liudmila, Guggino William B
Abstract excerpt
The PDZ domain-containing protein CAL mediates lysosomal trafficking and degradation of CFTR. Here we demonstrate the involvement of a CAL-binding SNARE protein syntaxin 6 (STX6) in this process. Overexpression of STX6, which colocalizes and coimmunoprecipitates with CAL, dramatically reduces the steady-state level and stability of CFTR. Conversely, overexpression of a STX6 dominant-negative mutant increases...
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