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Article

Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.

Molecular biology of the cell - 1 Apr 2010

Cheng Jie, Cebotaru Valeriu, Cebotaru Liudmila, Guggino William B

Abstract excerpt

The PDZ domain-containing protein CAL mediates lysosomal trafficking and degradation of CFTR. Here we demonstrate the involvement of a CAL-binding SNARE protein syntaxin 6 (STX6) in this process. Overexpression of STX6, which colocalizes and coimmunoprecipitates with CAL, dramatically reduces the...

Read the complete abstract on PubMed

Topics

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Share to RNA, Small Interfering
Share to Adaptor Proteins, Signal Transducing
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Dominant

Share to Membrane Transport Proteins

Share to Microscopy, Confocal

Share to Qa-SNARE Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20130090
DOI: 10.1091/mbc.e09-03-0229
PMCID: PMC2847522

Genes

CFTR
STX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20130090-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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