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Article

Targeting CAL as a Negative Regulator of ΔF508-CFTR Cell-Surface Expression

12 Dec 2006

Abstract excerpt

PDZ domains are ubiquitous peptide-binding modules that mediate protein-protein interactions in a wide variety of intracellular trafficking and localization processes. These include the pathways that regulate the membrane trafficking and endocytic recycling of the cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial chloride channel mutated in patients with cystic fibrosis. Correspondingly, a...

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Identifiers

PMID: 17158866
DOI: 10.1074/jbc.m611049200

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting CAL as a Negative Regulator of ΔF508-CFTR Cell-Surface ExpressionPMID 17158866Read ↗

The Relative Binding Affinities of PDZ Partners for CFTR: A Biochemical Basis for Efficient Endocytic RecyclingSemantic proximity Read ↗

Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

Sorting Nexin 27 (SNX27): A Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) TraffickingSemantic proximity Read ↗

PDZ Structure and Implication in Selective Drug Design against Cystic Fibrosis.Semantic proximity Read ↗

Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis.Semantic proximity Read ↗

Inhibition of the QPCT-PDIA4 axis rescues ΔF508 and N1303K CFTR in cystic fibrosis.Semantic proximity Read ↗

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partnersSemantic proximity Read ↗

Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR ActivitySemantic proximity Read ↗

Direct interaction with filamins modulates the stability and plasma membrane expression of CFTRSemantic proximity Read ↗

The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.Semantic proximity Read ↗

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read ↗

Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.Semantic proximity Read ↗

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