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Article

A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri

3 Feb 2010

Abstract excerpt

The virulence gene icsA of Shigella flexneri encodes an invasion protein crucial for host colonization by pathogenic bacteria. Within the intergenic region virA-icsA, we have discovered a new gene that encodes a non-translated antisense RNA (named RnaG), transcribed in cis on the complementary strand of icsA. In vitro transcription assays show that RnaG promotes premature termination of transcription of icsA...

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PMID: 20129941
DOI: 10.1093/nar/gkq025

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