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Article

Interlaboratory development and validation of a HRM method applied to the detection of JAK2 exon 12 mutations in polycythemia vera patients.

PloS one - 26 Jan 2010

Ugo Valerie, Tondeur Sylvie, Menot Marie-Laurence, Bonnin Nadine, Le Gac Gerald, Tonetti Carole, Mansat-De Mas Veronique, Lecucq Lydie, Kiladjian Jean-Jacques, Chomienne Christine, Dosquet Christine, Parquet Nathalie, Darnige Luc, Porneuf Marc, Escoffre-Barbe Martine, Giraudier Stephane, Delabesse Eric, Cassinat Bruno

Abstract excerpt

BACKGROUND: Myeloproliferative disorders are characterized by clonal expansion of normal mature blood cells. Acquired mutations giving rise to constitutive activation of the JAK2 tyrosine kinase has been shown to be present in the majority of patients. Since the demonstration that the V617F mutat...

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Source

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Identifiers

PMID: 20126644
DOI: 10.1371/journal.pone.0008893
PMCID: PMC2811183

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20126644-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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