Article
A highly sensitive quantitative real-time PCR assay for determination of mutant JAK2 exon 12 allele burden.
PloS one - 1 Jan 2012
Kjær Lasse, Westman Maj, Hasselbalch Riley Caroline, Høgdall Estrid, Weis Bjerrum Ole, Hasselbalch Hans
Abstract excerpt
Mutations in the Janus kinase 2 (JAK2) gene have become an important identifier for the Philadelphia-chromosome negative chronic myeloproliferative neoplasms. In contrast to the JAK2V617F mutation, the large number of JAK2 exon 12 mutations has challenged the development of quantitative assays. We present a highly sensitive real-time quantitative PCR assay for determination of the mutant allele burden of JAK2...
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