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Article

Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction.

Nature cell biology - 1 Mar 2010

Eden Emily R, White Ian J, Tsapara Anna, Futter Clare E

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a critical determinator of cell fate. Signalling from this receptor tyrosine kinase is spatially regulated by progression through the endocytic pathway, governing receptor half-life and accessibility to signalling proteins and phosphatases. Endocytos...

Read the complete abstract on PubMed

Topics

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Share to Endoplasmic Reticulum
Share to Endosomal Sorting Complexes Required for Transport
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leupeptins

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Share to Microscopy, Electron

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Source

Identifiers

PMID: 20118922
DOI: 10.1038/ncb2026

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20118922-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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