Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic inactivation of the MIR34B/C in multiple myeloma

6 Oct 2011

Abstract excerpt

We postulated that MIR34B/C, a direct transcriptional target of TP53, might be inactivated by promoter hypermethylation in multiple myeloma (MM). MIR34B/C promoter methylation was studied in 8 normal marrow controls, 8 MM cell lines, 95 diagnostic, and 23 relapsed/progressed MM samples by methylation-specific PCR. MIR34B/C was methylated in 6 (75.0%) MM cell lines but not normal controls. 5-Aza-2'-deoxycytidine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21976676
DOI: 10.1182/blood-2011-06-361022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic inactivation of the MIR34B/C in multiple myelomaPMID 21976676Read ↗

Epigenetic inactivation of the miR-34a in hematological malignanciesSemantic proximity Read ↗

Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impactSemantic proximity Read ↗

The Role and Function of microRNA in the Pathogenesis of Multiple MyelomaSemantic proximity Read ↗

Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?Semantic proximity Read ↗

Aberrant micro<scp>RNA</scp> expression in multiple myelomaSemantic proximity Read ↗

Deregulation and Targeting of TP53 Pathway in Multiple MyelomaSemantic proximity Read ↗

MicroRNA: Important Player in the Pathobiology of Multiple MyelomaSemantic proximity Read ↗

MiRNA as a Potential Target for Multiple Myeloma Therapy–Current Knowledge and PerspectivesSemantic proximity Read ↗

MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow MicroenvironmentSemantic proximity Read ↗

MicroRNA expression patterns and target prediction in multiple myeloma development and malignancySemantic proximity Read ↗

Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascadeSemantic proximity Read ↗

MicroRNAs in the Pathobiology of Multiple MyelomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.