Article
Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin.
Blood - 13 May 2010
Chu Charles C, Catera Rosa, Zhang Lu, Didier Sebastien, Agagnina Briana M, Damle Rajendra N, Kaufman Matthew S, Kolitz Jonathan E, Allen Steven L, Rai Kanti R, Chiorazzi Nicholas
Abstract excerpt
Many B-cell chronic lymphocytic leukemia (CLL) monoclonal antibodies (mAbs) can be grouped into subsets based on nearly identical stereotyped sequences. Subset 6 CLL mAbs recognize nonmuscle myosin heavy chain IIA (MYHIIA). Herein, we report that during apoptosis, MYHIIA becomes exposed on the cell surface of a subgroup of apoptotic cells, allowing subset 6 CLL mAbs to bind with it. Because other non-subset 6 CLL...
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