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Article

Nonstereotyped Lymphoma B Cell Receptors Recognize Vimentin as a Shared Autoantigen

28 Mar 2013

Abstract excerpt

Ag activation of the BCR may play a role in the pathogenesis of human follicular lymphoma (FL) and other B cell malignancies. However, the nature of the Ag(s) recognized by tumor BCRs has not been well studied. In this study, we used unbiased approaches to demonstrate that 42 (19.35%) of 217 tested FL Igs recognized vimentin as a shared autoantigen. The epitope was localized to the N-terminal region of vimentin...

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PMID: 23536634
DOI: 10.4049/jimmunol.1300179

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