Article
Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2010
Wang Jingying, Ma Heng, Tong Chao, Zhang Hanying, Lawlis Gavin B, Li Yuanda, Zang Mengwei, Ren Jun, Nijland Mark J, Ford Stephen P, Nathanielsz Peter W, Li Ji
Abstract excerpt
Maternal obesity in pregnancy predisposes offspring to insulin resistance and associated cardiovascular disease. Here, we used a well-established sheep model to investigate the effects of maternal obesity on cardiac functions. Multiparous ewes were assigned to a control (CON) diet [100% of National Research Council (NRC) recommendations] or an obesogenic (OB) diet (150% of NRC recommendations) from 60 d before...
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