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Article

Maternal obesity impairs fetal cardiomyocyte contractile function in sheep

5 Oct 2018

Abstract excerpt

ABSTRACT Obesity is a major public health problem worldwide. In the United States, one‐third of women of reproductive age are obese. Human studies show that maternal obesity (MO) predisposes offspring to cardiovascular disease. However, the underlying mechanisms remain unclear. Given the similarities between pregnancy in sheep and humans, we studied sheep to examine the impact of MO on fetal cardiomyocyte...

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PMID: 30289749
DOI: 10.1096/fj.201800988r

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